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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • New Vici Syndrome Mouse Model Could Accelerate Research

    Most rare diseases have a genetic component, making access to an animal model with the associated gene mutation a must for developing new therapies. Yet these diseases don't often attract the funding to develop a genetically engineered model of the condition. With the help of... Read more

  • CRISPR Genome Engineering: Advantages and Limitations

    Four years after the debut of CRISPR/Cas9 in mouse genetics, it is time to start drawing some conclusions on its performance, advantages, and limitations as a genome engineering technology1,2,3. Advantages of CRISPR Genome Engineering Arguably, the most important advantages of CRISPR/Cas9 over other genome editing... Read more

  • Why Your Transgenic Project Failed

    Erroneous modification of the mouse genome can lead to the generation of transgenic lines carrying non-functional alleles or unwanted mutations. These faulty models can seriously impact your research program, wasting resources on misleading results. Are Design Errors Driving Translational Failure? Genetically modified mouse models first... Read more

  • Mouse Model of Alcohol Abuse Shows Microbiome Changes

    In one of the few published studies evaluating the role of chronic alcohol exposure and its impact on the microbiome, researchers at University College Cork, National Institute on Alcohol Abuse and Alcoholism, and Teagasc Food Research Centre found marked changes in microbiota in a mouse... Read more

  • Mutation Reduces Immune Response in C57BL/6J Mice

    Researchers from the University of Iowa inadvertently identified an Nlrp12 missense mutation which inhibits immune responses in C57BL/6J mice. Further investigation reveals the mutation occurred prior to 1971, potentially impacting decades of research conducted on affected mouse models. Reduced Neutrophil Recruitment in C57BL/6J In this... Read more

  • Producing Neurological Symptoms in Mouse Model of Zika Virus

    Severity of 2015 Outbreak Fuels Research Zika virus (ZIKV) is a flavivirus transmitted primarily through mosquito bites. It was first discovered in 1947, and outbreaks described from the 1960s through 1980s were associated with mild illness in affected humans. A Brazilian outbreak in 2015, however,... Read more

  • Segmented Filamentous Bacteria in Mice

    In 2009, Dan Littman's laboratory published a landmark manuscript that greatly influenced how the research community viewed commensal microbes and their impact on the host immune system. Despite the presence of hundreds of species of bacteria in the intestinal tract, Ivanov et al. demonstrated that... Read more

  • Genetically Engineered Models in Drug Development

    Why do 90% of compounds fail the FDA approval process after entering Phase I clinical trials?1 Many failed projects can be traced to unreliable preclinical assessments of toxicity and efficacy of the potential new drugs2 – often due to a lack of predictive and reliable... Read more