Gut Check: The Microbiome in Preclinical Immuno-oncology Research

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • How Does the Microbiome Affect Your Mouse Model?

    Lactobacillus reuterii Induces Gut Intraepithelial CD4+CD8αα+ T Cells Researchers are still determining the full effect of the gut microbiota on immune system development. The best known example being reliance of Th17 responses on the presence of segmented filamentous bacteria (SFB). This past August, researchers at... Read more

  • Flu on the Fly

    Autumn, when leaves, pumpkin spice, and flu are in the air, is a time to evaluate animal models of influenza pathogenesis and developments in flu research and treatment. This is an introductory reference for influenza studies with a few tips and tricks for utilizing mouse... Read more

  • Resources for Improving Quality and Reproducibility in Animal Studies

    Quality and reproducibility are the focus of much scientific literature, reviews, and commentaries. Knowledge cannot advance without confidence in the reproducibility of our research. If you work in a laboratory animal facility or use animal models in your research, you know proper training is imperative... Read more

  • Time-restricted Feeding to Prevent Obesity in Juveniles?

    There is a growing body of evidence that time-restricted feeding (TRF), for example limiting eating to the active versus inactive phase for a particular species, can impact weight gain and development of obesity. Researchers at the Norwegian University of Science and Technology, the Central Norway... Read more

  • Care of Immunodeficient Mice and Rats

    Immunodeficient rodents require special husbandry and housing in order to remain healthy and provide optimum experimental performance. Below are recommendations for care and housing of immunodeficient rodents. Upon Delivery of Immunodeficient Rodents Most facilities receive multiple animal deliveries on the same day. These shipments carry... Read more

  • A Redox Link between APOE4 and Alzheimer's Disease Risk?

    A Redox Link between APOE4 and Alzheimer's Disease Risk? Individuals homozygous for APOE4, one of three common genetic variants encoding Apolipoprotein E (apoE), carry approximately twelve-times higher risk for an Alzheimer's disease (AD) diagnosis. A recent study suggests a potentially critical link between apoE4 and... Read more

  • Hot Topics at AALAS National Meeting 2017

    During the week of October 15, 2017, I attended the 68th National AALAS meeting in Austin, Texas. It has been almost twenty years since I attended my first AALAS National meeting, and it was an excellent opportunity to meet new people and reconnect with colleagues... Read more

  • Foundational Gnotobiotics Concepts

    Gnotobiology isn't new, but the dramatic expansion of microbiome research has outpaced the development of a common nomenclature within the gnotobiotic research community. Many different, and sometimes confusing, terms are used when referring to different gnotobiotic concepts. To help, here's an overview of the most... Read more