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  • SFB and Immune Response in Animal Models

    Segmented filamentous bacteria (SFB, provisional classification Candidatus Savagella) are commensal microorganisms endemic to all vertebrate classes, including mice and humans. SFB are notable for their ability to modulate adaptive host immune responses, including induction of regulatory Th17 T cells, Peyer's patch maturation, and gut IgA... Read more

  • PD-1 Blockade Ineffective in AD Mouse Models

    More than 45 million people worldwide suffer from Alzheimer's disease (AD) or dementia. The costs are staggering, and no cure exists. Development of new therapies has been challenging, with many promising new drugs failing in late stage clinical trials. Inducing Immune Response in AD Mouse... Read more

  • Webinar Q&A — Using Diet-Induced Obese Mice to Study Metabolic Disease

    In a recent webinar, Dr. Michael Briggs and Mrs. Nikole Siegmund of Woodland Biosciences discussed use of diet-induced obese (DIO) mice for metabolic disease research. The speakers explained how DIO mice can be used in a range of study types, including: Obesity reduction Obesity-related inflammation... Read more

  • New PBMC-humanized Mice Support Efficient NK-cell Engraftment

    Favored for their relative speed, versatility, and translational relevance, humanized mice engrafted with human peripheral blood mononuclear cells (PBMCs) are the go-to preclinical models for evaluating T-cell-dependent immunotherapies. However, lacking important human cytokine signals, huPBMC-NOG and other PBMC models fail to support engraftment of important... Read more

  • Webinar Q&A — Next Generation Humanized Mice in IO

    The preclinical research community responded enthusiastically to Dr. Paul Volden's recent webinar, Next Generation Humanized Mice in Immuno-Oncology, the second webinar in a two-part series on humanized mice for preclinical immuno-oncology (IO). Several questions had to be cut from the presentation for time and are... Read more

  • Introduction to Translational Microbiome Research Infographic

    Download Taconic Biosciences' new infographic, Translational Microbiome at a Glance, for valuable insights into the translational aspects of microbiome research. Intended for those just beginning their work, Translational Microbiome at a Glance covers critical introductory subjects such as: The six factors that shape the mouse... Read more

  • Application of CRISPR/Cas to the Generation of Genetically Engineered Mice White Paper

    UPDATE: This White Paper has been updated in 2018 to reflect the latest technological advances and usage recommendations of CRISPR/Cas in the generation of research models. CRISPR/Cas gene editing has emerged as a versatile technology for inducing precise genetic alterations in a number of different... Read more

  • The Long-Term Impacts of Traumatic Brain Injury

    National Vital Statistics System Mortality Data — United States, 2001-2010 (Deaths) Traumatic brain injury (TBI) is a growing problem. An estimated 10 million people are affected annually worldwide by TBI, and the burden of mortality and morbidity that imposes on society makes TBI a pressing... Read more