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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Introduction to Embryo Cryopreservation

    This is the second of a four-part series on the effective use of cryopreservation in maintaining genetically modified mouse and rat lines: Cryopreservation in Colony Management Introduction to Embryo Cryopreservation Sperm Cryopreservation Overview Cryopreservation Decision Tree Embryo Cryopreservation Overview Until recently, cryopreservation of two-cell stage... Read more

  • Evaluating Vaccines in Humanized Mice

    Human Vaccine Evaluation in a Novel Humanized Immune System Mouse The evaluation of specific antibody production requires an in vivo model; however, species differences limit the utility of experimental animals for this purpose. For example, the lack of interspecies homology between the T cell receptor... Read more

  • Cryopreservation in Colony Management

    Use of genetically engineered rodent models in research requires the lines to be maintained in continuous breeding, which is costly, labor intensive, and takes up limited vivarium space. Also when such colonies are the sole source of the model, there is risk of losing the... Read more

  • An Orphan no more: GFRAL identified as receptor for weight regulator GDF15

    While wild type mice administered GDF15 lose weight, Gfral knockout mice are resistant to the effects of GDF15. Figure from Hsu, J-Y, et al1. Four independent research groups recently identified the previously orphan receptor GFRAL as the receptor for GDF15. The simultaneous publications, one in... Read more

  • Book Review: Gnotobiotics

    Gnotobiotics, edited by Trenton Schoeb and Kathryn Eaton, is invaluable to those developing or managing gnotobiotic facilities. The book is part of the American College of Laboratory Animal Medicine Series, published by Elselvier, and covers a number of species including rodents, swine and fish. It... Read more

  • Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome

    Researchers have identified measurable effects of exercise on the gut microbiome in mice, according to a study published in mSystems. In "Moderate Exercise Has Limited but Distinguishable Effects on the Mouse Microbiome," researchers at Dalhousie University, Canada, compared gut microbial diversity and changes in exercise-associated... Read more

  • Seeing the Microbiome with Fresh Eyes

    Anthony St. Leger and colleagues from the National Eye Institute at the National Institute of Health (NIH) recently published evidence that the ocular microbiome plays an important immunological role1. The Ocular Microbiome The surface of the human body is colonized by a diverse community of... Read more

  • TH17-Inducing Gut Bacteria Can Promote Autism-like Behavior in Mouse Pups

    Segmented filamentous bacteria (SFB) in the terminal ileum of an 8-week-old Taconic B6 mouse On September 13, 2017 researchers from the Massachusetts Institute of Technology and the University of Massachusetts Medical School simultaneously published papers in Nature on the same intriguing topic: a link between... Read more