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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Microbiome Articles in the Top 5 of Articles Read in 2017

    The Translational Scientist Journal announced the top 5 articles of 2017 from their publication. Two of the five articles examine the microbiome; further supporting its stature in life sciences research. Microbiome research continues to be a popular discussion topic for articles, conferences, and in the... Read more

  • Does Roundup® Residue on Food Impact your Microbiome?

    The herbicide glyphosate (Roundup® and other tradenames) works by inhibiting synthesis of aromatic amino acids in the shikimate pathway, which is active in plants as well as bacteria, but not in mammalian species. Thus while glyphosate cannot adversely affect humans via its primary mode of... Read more

  • Gut Microbiome and the Efficacy of Cancer Immunotherapy

    Two new studies in humans published in Science in November 2017 support previous findings in mice: that response to cancer therapy is dependent on the gut microbiome1,2. This opens the possibility for researchers to explore deliberate exploitation of the microbiome in improving the efficacy of... Read more

  • Webinar Review: Genetic Integrity in Breeding Colonies

    What is genetic quality and how does it impact in vivo research? Dr. Ana Perez addressed this topic in a recent webinar, making the case that research reproducibility requires high genetic quality of laboratory rodents. Genetic Background Categories In terms of their genetic background, Dr.... Read more

  • National Drug and Alcohol Facts Week

    During the third week of January The National Institute on Drug Abuse (NIDA) and National Institute on Alcohol Abuse and Alcoholism (NIAAA) host an annual event focusing on substance abuse and its impact on teenagers. Launched in 2010, the National Drug Alcohol Facts Week (NDAFW)... Read more

  • Breakthrough Model for Immunotherapy Research

    Rodent models engrafted with human immune cells are important tools for preclinical evaluation of immunotherapies. However, humanized immune system (HIS) models have largely failed to support the long-term engraftment and survival of human natural killer (NK) cells, an immune cell population that is essential to... Read more

  • Animal Research Sample Size Calculation (and Consequences)

    Proper sample size calculation is both a scientific and ethical imperative. Researchers are routinely asked to justify the number of animals used in their studies, either by regulatory bodies, funding agencies or, increasingly, by journal editors. In accordance with the 3R's, studies should be designed... Read more

  • Webinar Review: How to Harness the Microbiome

    Rodent model microbiomes introduce confounding effects in an alarming range of study endpoints. In a recent webinar, Aaron Ericsson, Research Assistant Professor and Director of Metagenomics at the University of Missouri, reviewed emerging best practices to identify and control for relevant microbiota, improving the accuracy... Read more