The Diet Induced NASH B6: A Translational NASH Model for Drug Discovery

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Adipose Tissue and Hormone Regulation

    The incidence of metabolic disease and the number of obese patients in the US is growing at an alarming rate. While the Western diet and lack of exercise may be to blame for some, there are complex biological processes that underlie the progression of obesity... Read more

  • Build or Buy: Animal Model Licensing in the Age of CRISPR

    Genetically modified mice and rats have been around for decades. But, until recently, the cost and effort involved in generating genetically engineered models (GEMs) using the available technologies were relatively high. This meant that requesting access to a model described in the literature was the... Read more

  • International NASH Day

    The second annual International NASH Day took place on June 12, 2019. This day of action was launched last year to bring awareness to the global epidemic of NASH (nonalcoholic steatohepatitis). A coalition of worldwide organizations supported this effort including the American Liver Foundation, the... Read more

  • FDA Issues Safety Alert on Investigational Use of Fecal Microbiota Transplantation

    Fecal microbiota transplantation (FMT) is the transfer of fecal matter from a healthy individual into a recipient with the goal of treating an ailment. In its simplest form FMT has been used to treat disease with reports detailing its use as far back as 1700... Read more

  • What is a Xenograft?

    The term xenograft refers to a tissue or organ that is derived from a species that is different from the recipient of the specimen. They are powerful research tools in oncology as well as essential for treating wounds in the clinic. This Insight will highlight... Read more

  • Mitochondrial DNA and Cellular Metabolism

    Inside each cell exist many complex smaller structures known as organelles. These micrometer-sized structures work to maintain intracellular transport, signaling, energy production, protein translation, DNA replication, and other essential cellular processes. One organelle which differs distinctly from others is the mitochondrion. In addition to generating... Read more

  • Iron, Oxidative Stress, and Cancer Risk

    Oxidative stress is defined as "a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses1". Long term oxidative stress on cells has been shown to be a key promoter of the development of disease; particularly cancer, diabetes, atherosclerosis,... Read more

  • Should You Have a Lab Animal Health Status or Standard?

    When considering animal health in your research or ordering mice from a commercial provider, which is more significant: a health status or a health standard? While the words "status" and "standard" seem similar, there are clear differences in their definitions and how you might apply... Read more