Precision Research Models

Humanized mice support more translatable preclinical research by enabling in vivo study of functional human immune systems, tissue, and organs in animal models:

  • Design more relevant preclinical studies
  • Streamline your drug discovery programs
  • Develop translatable clinical insights
  • Demonstrate efficacy and safety more efficiently
Humanized mouse models are powerful tools for advancing preclinical research in biomedical research, drug discovery, and efficacy testing.

Immune System Engrafted Mice

Taconic Biosciences' NOG mice are immunodeficient mouse models which accept the engraftment of heterologous cells more readily than traditional immunodeficient models, making them exceptional candidates for the production of mice with human immune systems.

The ability to efficiently engraft and proliferate a functional human immune system in NOG mice supports in vivo research in a more translatable context, powering studies in a variety of applications.

Examples include:

  • Basic immune system and hematopoiesis research
  • Infectious disease models of human-specific pathogens
  • Translatable efficacy testing of immunotherapies
  • More robust safety testing for novel therapeutics
  • Preclinical research into Graft vs. Host Disease (and other transplantation applications)
  • Streamlined vaccine development
  • Humanized autoimmune disease research models

Taconic offers three fully-characterized strains of mouse models engrafted with a human immune system:

  1. huNOG: NOG mice engrafted with human CD34+ hematopoietic stem cells (HSCs).
  2. huPBMC-NOG: Human peripheral blood mononuclear cell (PBMC) engrafted mice, optimally suited for Graft vs. Host Disease (GvHD) studies and as a screening system T cell-modulating drugs.
  3. huNOG-EXL: A super-immunodeficient NOG mouse expressing human GM-CSF and IL-3 cytokines for increased engraftment and proliferation of a functional human immune system, with applications in cancer, infectious disease, allergy, immunology, and regenerative medicine research.

Genetically Humanized Mice

Next-generation humanized mouse models emerge from the core NOG portfolio, with additional genetic modifications for increased translatability and effective modeling of the human immune system in a preclinical context.

Examples of these transgenic modifications include, but are not limited to:

  • Expression of human cytokines to support myeloid lineage development
  • Deletion of major murine histocompatibility complex (MHC) genes to study human MHC-reactive T cells
  • Modifications to enable human liver reconstitution in mouse models
Taconic currently offers five strains of next-generation humanized mice, with additional models undergoing development and characterization:

  1. NOG-EXL (hGM-CSF/hIL-3 NOG): NOG mice expressing transgenic human GM-CSF and human IL-3.
  2. TK-NOG: NOG mice with transgenic expression of thymidine kinase under control of liver-restricted albumin promoter.
  3. hIL-2 NOG: Super-immunodeficient NOG mice expressing transgenic human IL-2 cytokine, with ten-fold higher CD56+ NK cell numbers compared to the base NOG mouse.
  4. hIL-6 NOG: IL-6 cytokine-expressing humanized mouse models with multiple applications in cancer and immunology research.
  5. hIL-15 NOG: Mice expressing human IL-5 cytokines with applications in the assessment of antibody therapeutics and cell cytotoxicity.

Contact Taconic Biosciences Learn more about how Taconic can help you with your Humanized Mice needs: