Alzheimer's Disease Models

Amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) combined with deficits in learning and memory are hallmarks of Alzheimer’s Disease (AD). Understanding how plaques and tangles are formed and discovering effective therapeutics that prevent these neurodegenerative processes are important factors for winning the battle against Alzheimer’s Disease.

As part of Taconic's Neuroscience Portfolio, we offer a variety of transgenic rodent models that develop plaques and tangles and allow screening of novel drug candidates for treatments against Alzheimer’s and other neurodegenerative diseases.

What our customers say:

“Taconic Biosciences has been an invaluable resource for the entire Alzheimer's disease (AD) research community. As an academic researcher that builds animal models of sporadic AD I cannot possibly supply the community's needs for these models, but instead depend on Taconic to fulfill this role. My hope is that as new and improved models become characterized and validated, that the research community at large will supply these models to Taconic to manage and distribute.”

Patrick Sullivan, PhD, Associate Professor of Geriatrics at a major university
Alzheimer's Disease Models Learn more about:

Familial AD Models:

View a timeline of neuropathology of these mouse models as well as amyloid plaque development in the APPSWE mouse brain.

Sporadic AD Models:

Learn about the benefits of using sporadic AD mouse models for studying the role of human APOE polymorphism neurodegenerative disorders.