Humanized and Knockout Mouse Models For In Vivo Applications
Drug transporters mediate uptake and extrusion of many compounds across biological barriers and can have profound effects on absorption, distribution metabolism, excretion, and toxicity (ADMET) of potential therapeutics. There is an increasing requirement to understand the role of such transporters on the ADMET characteristics of compounds in drug development, as highlighted by the recent white paper from the International Transporter Consortium (Nat Rev Drug Discov. 2010 Mar; 9(3):215-36). We offer a unique portfolio of transporter humanized and knockout mouse models which can be used for different in vivo applications.