Taconic Insights

Biopharmaceutical Trends and R&D

Taconic Biosciences has remained one of the world's leading providers of research models and services for over 60 years through our commitment to anticipating clients’ needs and industry trends. One of the key trends of the past ten years involves our clients’ need to strategically outsource functional areas of their R&D programs. When companies, academic institutions, government agencies and others outsource certain R&D functions they begin to rely on their collaborators, such as Taconic, to keep them apprised of emerging science and technologies in our specific areas of expertise.
In this spirit of collaboration, we present "Taconic Insights", a new section of our website dedicated to educating the industry on key scientific and technological trends impacting biopharmaceutical R&D. Here you will find the latest insights Taconic can provide in the form of articles, white papers, videos, webinars, presentations, and other media.

CRISPR Update Broad vs. Berkeley

It was recently announced that the legal battle over the CRISPR/Cas9 patents is likely finished with the Broad Institute prevailing above UC Berkeley. This ongoing debate began in 2014 with multiple research groups and institutions claiming rights to the CRISPR/Cas9 technology. The researchers involved in this case are Dr. Jennifer Doudna (UC Berkeley) and Dr. Emmanuelle Charpentier (University of Vienna) who engineered the Cas9 endonuclease from a...

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Investigating Tauopathies with Transgenic Mice

In a recent manuscript by Musi and co-authors, a combinatorial approach was adopted to investigate the tauopathy-mediated mechanisms underlying human Alzheimer's Disease (AD) in post-mortem human brain tissue and transgenic mice1. Human neurodegenerative diseases comprise a heterogenous group of disorders, underpinned by complex interactions of cell-intrinsic and -extrinsic molecular mechanisms between multiple different neuronal and non-neuronal cell types. Understandably, the spatio-temporal isolation and investigation of specific pathogenic...

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2018 Nobel Prize in Physiology or Medicine Awarded to Two Immunologists

Source: Karolinska Institutet On Monday, October 1, 2018 the Nobel Committee announced the recipients of this year's Nobel Prize in Physiology or Medicine. The two Nobel laureates were James P. Allison — a professor and immunologist from MD Anderson Cancer Center — and Tasuku Honjo — an immunologist from Kyoto University. Both researchers split the prize evenly for their pioneering discoveries relating to "cancer therapy inhibition of...

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Transgenic Mice Play a Key Role in Global Polio Eradication Initiative (GPEI)

Humanity is on the verge of one of the greatest public health achievements in history — eradicating polio. The Global Polio Eradication Initiative (GPEI) has reduced polio cases by 99.9% since 1988, bringing the world closer than ever to ending polio for good. This means a world in which every child would be safe from the paralysis caused by the virus. What is Polio? Poliomyelitis (polio) is...

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Webinar Q&A — Cyclical Bias

In a recent webinar, Dr. Alex Rodriguez-Palacios of Case Western Reserve University School of Medicine discussed a confounding influence on many common microbiome study endpoints uncovered in studies using the NesTiso system. The NesTiso system has been described in a previous publication1 and examined in an on-demand webinar. Due to time constraints, some of the questions you submitted to our Q&A session went unanswered. We present here...

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Breast Cancer Awareness Month

October is National Breast Cancer Awareness Month. There is a lot to be excited about this year as mortality rates continue to drop for major cancer types, including breast cancer. Between 1989 and 2015 deaths from breast cancer specifically declined 39%, a decline American Cancer Society attributes to "improvements in early detection." There's still work to be done, however. An estimated 270,000 new cases of breast cancer...

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Mountain Cottages, Fresh Air, and TB Research

A Tuberculosis Directory by Philip P. Jacobs. 1911. National Association for the Study and Prevention of Tuberculosis. After centuries of research tuberculosis (TB) has dropped from one of the leading causes of death in the 19th century to the ninth, worldwide. How did we accomplish this and can we maintain control of the disease in the era of drug-resistant TB infections? A Short History of TB There...

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Pancreatic Cancer Microbiome Suppresses Immune Responses

Alterations in the microbiome have an acknowledged role in cancer pathology1,2. Earlier this year, however, researchers at New York University published a manuscript3 connecting the pancreatic microbiome to cancer progression. In this report, Pushalkar et al. demonstrate that the endogenous microbiome of the pancreas can drive immunosuppressive conditions in humans and mice, which creates a pro-tumorigenic state. Treatment regimens that include modulating the microbiome show promise for...

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Round Up: Top 5 Insights from the Summer 2018

Here's our recap of the top Insight posts from the summer you might have missed! 1. Translational Microbiome Infographic Are you beginning your studies in the Microbiome and don't know where to start? Download and print out the Translational Microbiome at a Glance Infographic to give you a quick reference into this valuable area of research — Find out more! 2. New PBMC-Humanized Mice Support Efficient NK-Cell...

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CASIS Announces Request for Proposals to Access Spaceflight Biospecimens

Source: CASIS The Center for the Advancement of Science in Space (CASIS) recently announced a Request for Proposals (RFP) for investigators seeking to access biological specimens from its Rodent Research Reference Mission-1, Applications for Spaceflight Biospecimens. The BALB/c mice for the space flight are provided by Taconic Biosciences. Taconic Biosciences has provided mice and rats for spaceflight research since 1985. CASIS intends to send 40 BALB/c mice...

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