Cardiovascular and Metabolic Disease INSIGHTS


An Orphan no more: GFRAL identified as receptor for weight regulator GDF15

While wild type mice administered GDF15 lose weight, Gfral knockout mice are resistant to the effects of GDF15. Figure from Hsu, J-Y, et al1. Four independent research groups recently identified the previously orphan receptor GFRAL as the receptor for GDF15. The simultaneous publications, one in Nature1 and three in Nature Medicine2,3,4, show that GFRAL expression is restricted to brainstem regions in mice and that GDF15 acts through...

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Modified DIO Protocols Improve Type 2 Diabetes Models

Animal models of diet-induced obesity (DIO) are commonly used to model metabolic syndrome, but have some limitations. Can a modified DIO protocol produce better type 2 diabetes models? Developing Modified DIO Protocols DIO C57BL/6 mice are obese, glucose intolerant, insulin resistant, and display mild hyperglycemia. To better model Type 2 diabetes, researchers at the University of Colorado and NYU Langone Medical Center recently developed a modified protocol...

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Animal Models of Type 2 Diabetes: The GK Rat

Studying the long-term complications of diabetic pathology is more relevant than ever, driving increased interest in animal models of type 2 diabetes. According to the World Health Organization (WHO) the number of people with diabetes (includes both type 1 and type 2) has risen from 108 million in 1980 to 422 million in 2014. "[Diabetes] is a major cause of blindness, kidney failure, heart attacks, stroke, and...

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Does Vascular Catheterization in Mice Impact Health?

Vascular catheterization is commonly used to sample blood and administer compounds to mice and rats, but does it have physiological impact? Researchers may assume that catheterization and automated blood sampling has no effect on the test subject, but a new study sheds doubt on that assumption. Researchers at the University of Copenhagen and the Karolinska Institutet published a paper titled "Carotid Catheterization and Automated Blood Sampling Induce...

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Q&A: Diet Induced Obese Mice

Taconic Biosciences' Product Manager Jennifer Phelan recently presented a webinar on diet-induced obesity (DIO) in mouse models and the production of obese mice, including important factors in housing and husbandry. Many of your questions went unanswered due to time constraints, so we present those additional questions and answers here: Currently, Taconic does not have in-house data on the diabetic neuropathy of C57BL/6NTac DIO mice, however several publications...

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C57BL/6 DIO 101: Best Practices for Diet Induced Obesity in Mice

A DIO (diet induced obese) mouse is a C57BL/6 - "Black 6" - mouse which has been made obese through conditioning with a special diet. These diets tend to be high in fat, however there are sometimes other modifications made such as added sugar and there are varying types of fat used to create the diet. View the Taconic Biosciences' Webinar: DIO 101: Diet-induced Obesity in Mice...

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