GEMs Management INSIGHTS


Should You Breed or Buy Your Own Rodent Models?

Many research investigators are faced with a decision: should they buy laboratory rodents from a commercial vendor, or produce them with an in-house breeding colony? There are many factors to evaluate before the decision to "breed or buy" can be made. Following are a few questions and considerations that must be addressed before an informed decision can be made: Are the rodents available from a commercial vendor?...

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'Collaborative Research Organizations' Are Your New CRO

Over the last two decades, the pharmaceutical industry has faced increasing challenges: declining R&D productivity, rising costs, competition from generics, greater regulatory complexity, and changing expectations of patient-centered healthcare. In response to these pressures, many companies are transforming the way in which medicines are discovered, developed, and brought to market. Two key trends are emerging: The proliferation of digital biotechs The externalization of drug development Contract Research...

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Cryopreservation Decision Tree

Use of genetically engineered rodent models in research requires maintaining the lines through some level of continuous breeding. This can be costly, labor intensive, and result in inefficient use of limited vivarium space — while leaving valuable genetic lines vulnerable to catastrophic loss and genetic drift. This Insight provides guidance on choosing between embryo or sperm cryopreservation based on the attributes of the model to be preserved....

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Sperm Cryopreservation Overview

Recent improvements in sperm cryopreservation and IVF protocols in mice established sperm cryopreservation as a reliable and efficient method for archiving and distributing genetically engineered mouse lines. Further, the ability to rapidly expand animal model colonies from frozen sperm make sperm cryopreservation a quick and effective method for the distribution and restoration of mouse lines. Sperm cryopreservation is the most common method for cryopreserving mouse lines. Sperm...

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Introduction to Embryo Cryopreservation

This is the second of a four-part series on the effective use of cryopreservation in maintaining genetically modified mouse and rat lines: Cryopreservation in Colony Management Introduction to Embryo Cryopreservation Sperm Cryopreservation Overview Cryopreservation Decision Tree Embryo Cryopreservation Overview Until recently, cryopreservation of two-cell stage or later stage embryos was the predominant method for preserving lines of laboratory rodent models. The methodology is relatively simple and does...

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Cryopreservation in Colony Management

Use of genetically engineered rodent models in research requires the lines to be maintained in continuous breeding, which is costly, labor intensive, and takes up limited vivarium space. Also when such colonies are the sole source of the model, there is risk of losing the line altogether to unanticipated death, disease, infertility, genetic drift, or microbial contamination. Effective use of cryopreservation allows researchers to better utilize financial...

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The Power of Laboratory Mice Infographic

Looking for an accessible primer on the state of laboratory mice in biomedical research? Download Taconic Biosciences' new infographic The Power of Laboratory Mice, or request the infographic as a poster. This laboratory mice infographic can be a helpful reference to those just beginning their work with in vivo research models, as well as to researchers with extensive experience in the lab. It presents information on how...

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A Successful Breeding Plan in Five Steps

"It's just breeding... right?" You may want to carry out large cohort studies within the next 4-6 months, or to quickly recover a cryopreserved line from your collaborator to cross with your own knockout line. How difficult can it be? The temptation of getting there fast may make you plunge into a new project right away. But early missteps in colony management can surface months into a...

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Easier Said than Bred: 4 Considerations for Breeding Laboratory Mice

Have you ever had a mouse infestation in your house? This is a pesky problem that can prove difficult to resolve. After all, they breed like... well, mice. So why is it so difficult to breed laboratory mice? Laboratory mice are purpose-bred for specific phenotypes or traits, not to optimize litter size. Quite often, fecundity is sacrificed to attain traits desired for laboratory mouse studies, or breeding...

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Additional Mouse Models Added To The Cancer Research Technology Repository

Taconic Biosciences has recently added an additional 6 mouse lines to the Cancer Research Technology (CRT) Repository as part of the Emerging Models collection. The CRT repository provides academic and non-profit researchers with worldwide access to multiple genetically engineered mouse models that may be particularly useful for cancer research. CRT is a specialist development and commercialization company, which aims to advance new discoveries in cancer research for...

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