Immunology and Inflammation INSIGHTS


Endocannabinoids Prevent Inflammation, Maintain Intestinal Homeostasis

The inflammatory bowel diseases (IBD) are conditions regulated by a combination of genetic, immune and microbial factors. Although it is a normal component of host defense against pathogens, neutrophil influx to the intestinal lumen is also associated with severe pathology in IBD. In a recent manuscript by Szabady et al., the authors demonstrate a novel role for endocannabinoid compounds in regulating intestinal inflammation by limiting neutrophil migration...

Read More

IBD and Immune Checkpoint Modulators

New research offers insights into the connection between regulatory T cells and ILC3-driven colitis, suggesting opportunities for checkpoint modulation therapies. Researchers at Merck and the University of Bern explored the role of FoxP3+ regulatory T cells (Treg cells) in innate lymphoid cell 3 (ILC3)-driven colitis. The researchers found that Treg cells inhibited production of the pro-inflammatory cytokines which drive ILC3 production of interleukin 22 (IL-22). They identified...

Read More

Evaluating Vaccines in Humanized Mice

Human Vaccine Evaluation in a Novel Humanized Immune System Mouse The evaluation of specific antibody production requires an in vivo model; however, species differences limit the utility of experimental animals for this purpose. For example, the lack of interspecies homology between the T cell receptor (TCR) repertoire and major histocompatibility complex (MHC) proteins precludes the evaluation of human vaccine responses in rodents. Humanized mice could be the...

Read More

Marvel Super Heroes Take on IBD

Takeda Pharmaceuticals has joined forces with Marvel Custom Solutions to develop a graphic novel in which the super heroes have Crohn's disease or ulcerative colitis, and other characters care for family members or patients with Inflammatory Bowel Disease (IBD). As part of a Takeda program called IBD Unmasked, the graphic novel was developed in partnership with Marvel. They consulted with an IBD advisory panel consisting of patients...

Read More

AAI Travel Grant Supports GvHD Researcher

Taconic AAI 2017 travel grant awardee, Trivendra Tripathi (left) and Taconic Field Applications Scientist, Philip Dubé Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the American Association of Immunologists in Washington, DC. As a postdoctoral fellow in the lab of Dr. HyeMee Joo at the Baylor Institute...

Read More

Key Immunology Mouse Models in History

While the field of immunology has origins that date back to the 1500s, the field gained significant ground with the expanded use of mouse model systems. Fundamental discoveries elucidated in mouse models over the past 50 years are beginning to yield major breakthrough treatments for the most sinister human diseases, including inflammatory bowel disease, neurodegeneration, and cancer. The immunologist's major professional association, the American Association of Immunology,...

Read More

Versatile Applications of the TNFα Mouse

Research models are often engineered to help answer a narrow set of experimental questions; however, cross-breedings and other experimental interventions allow investigators to dramatically broaden the utility of transgenic mouse models. This is particularly true for models with strong and relatively easy-to-monitor phenotypes, two properties which support a potential platform for multiple rapid discoveries. One such example is the human TNFα mouse: a transgenic mouse that over-expresses...

Read More

What's in a Name? Origins of the CIEA NOG mouse®

The CIEA NOG mouse® is often referred to as an ideal mouse for engraftment of foreign (especially human) cells. The high rates of engraftment make NOG mice a preferred choice for patient-derived xenografts and humanized immune system mice studies. What special properties make the NOG mouse such a great acceptor of foreign cells and tissues? To answer this question, one need only look at the mouse line's...

Read More

Guidelines for Use of Humanized Mice in IBD Drug Discovery

Inflammatory Bowel Disease (IBD) is a chronic immunologically mediated disease with no known cure. Can humanized mice speed up IBD drug discovery, bringing relief to the estimated 1.4 million Americans with this difficult condition? To support IBD research, Taconic Biosciences hosted a webinar by TransCure BioServices experts: Chief Executive Officer (CEO), Dr. Patrick Nef, and Chief Scientific Officer (CSO), Dr. Sebastien Tabruyn. TransCure is a contract research...

Read More

Conversion of Immunodeficient Rodent Models to Excluded Flora Health Standard

Taconic Biosciences is converting production of many immunodeficient models from the Restricted Flora™ (RF™) health standards to the Excluded Flora (EF) health profile as part of continuous quality improvements. The next model identified for conversion to Excluded Flora production is the NCr nude, with a target date for conversion by Dec 31, 2016. To ease your transition, free trials are available through the Smart Select program. We...

Read More