Oncology and Immuno-Oncology INSIGHTS


Video: Mouse Models Used to Study Immuno-oncology

Taconic Biosciences' Dr. Philip Dubé discusses mouse models used to study immuno-oncology in this video excerpt from the webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice". There are essentially two types of models used in pre-clinical immuno-oncology research: Syngeneic models — a mouse tumor is implanted into a genetically identical and immuno-competent host Humanized models — severely immuno-deficient mice are implanted with both a human immune...

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Seminar: Humanized Mice in Preclinical Bone Metastasis Studies

All are welcome to Biocom's continuing education seminar on the use of humanized mice in immuno-oncology and bone metastasis studies on April 12, 2018 at Larkspur Landing. Immuno-Oncology Seminar BioCom will hold an in-person continuing education seminar to explore new study design options in immuno-oncology supported by novel humanized mouse models, including a case study on how one particular humanized mouse could be used to study cancer...

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Taconic's Guide to AACR 2018

This April 22,000 scientists from nearly 100 countries will gather in Chicago for the American Association for Cancer Research 2018 Annual Meeting. Over the course of five days, 6,000 scientists will share results from recent studies, spurring discussion and debate. Attendees can visit 400 exhibitors showcasing new tools and technologies. Presentations at the annual meeting will cover the latest basic, translational, clinical, and prevention-focused research in the...

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Immunogenic peptide from PSF1 identified as potential new cancer vaccine target

Although much of the press for immuno-oncology (IO) has focused on checkpoint inhibitors, researchers are exploring many other types of IO therapeutics. Other types of IO therapies under development include bi-specific antibodies, CAR-T cells, and cancer vaccines. Researchers at Shionogi and Osaka University recently published a paper1 describing identification of a new tumor antigen with the potential for targeting via a cancer vaccine. Previous research showed that...

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Webinar Review: Immuno-oncology and the Microbiome

In a recent webinar, Dr. Benjamin Cuiffo of Biomodels addressed the role of microbiome in preclinical immuno-oncology research. There is growing evidence that microbial imbalance (dysbiosis) is associated with many illnesses, including inflammation, autoimmune disease, and even cancer — but many researchers fail to account for its impact in preclinical study design. If you missed it, here's a summary of the key developments discussed during Dr. Cuiffo's...

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Breakthrough Model for Immunotherapy Research

Rodent models engrafted with human immune cells are important tools for preclinical evaluation of immunotherapies. However, humanized immune system (HIS) models have largely failed to support the long-term engraftment and survival of human natural killer (NK) cells, an immune cell population that is essential to an increasing number of cancer therapies being developed. This was a significant barrier to progress in preclinical immuno-oncology research. In their latest...

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Care of Immunodeficient Mice and Rats

Immunodeficient rodents require special husbandry and housing in order to remain healthy and provide optimum experimental performance. Below are recommendations for care and housing of immunodeficient rodents. Upon Delivery of Immunodeficient Rodents Most facilities receive multiple animal deliveries on the same day. These shipments carry rodents of varying strains and health status. Rather than unpacking deliveries randomly, Taconic Biosciences recommends sorting transit cages based on immune status...

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Novel Humanized Mouse Model Mirrors Patient Responses to Immunotherapy

For the first time, a team of scientists reproduced clinical responses to adoptive T-cell transfer in a rodent model of metastatic melanoma. This could support more accurate preclinical evaluation of novel immunotherapy agents. As described in Nature Communications, University of Gothenburg researchers leveraged the super-immunodeficient CIEA NOG mouse® to establish metastatic melanoma patient-derived xenografts (PDX) for subsequent autologous adoptive cell therapy (ACT). The researchers report tumor eradication...

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Humanized Mice in Cancer Bone Metastasis Studies

Despite recent advances in cancer research and drug development, bone metastases remain incurable. Some of the most common cancers, such as breast, prostate, lung, and multiple myeloma frequently metastasize to bone1,2,3. As bone metastasis is difficult to treat and target, and because the bone itself is noted to induce drug resistance, the preclinical evaluation of new therapies in more translatable bone metastasis models may increase the likelihood...

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Considerations for Rodent Irradiation

Rodent irradiation is an important tool in immunology and oncology rodent studies and has been critical in learning about tumor biology, transplant biology and immune system function. Understanding the biophysical and biological factors involved in irradiation studies is critical for optimizing model performance and improving experimental results. Irradiation preferentially kills rapidly dividing cells, including bone marrow and epithelial cells of the gut and other organs. The most...

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