Oncology and Immuno-Oncology INSIGHTS

What is a Xenograft?

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The term xenograft refers to a tissue or organ that is derived from a species that is different from the recipient of the specimen. They are powerful research tools in oncology as well as essential for treating wounds in the clinic. This Insight will highlight a few key uses of xenografts and why they are important to research studies. Xenografts in the Treatment of Skin Injuries In...  Read More

Nude Mice, Xenografts, and Treating Baldness

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A recent article published in the Columbia Magazine highlights the work of researcher Angela Christiano and her radical solutions to addressing baldness. Dr. Christiano has been working on studies involving hair loss since 1996, with one of her most notable achievements being the discovery of a 'hairless gene' (HR) in 19981. One of her recent advancements in this field has been the growth of human hair follicles...  Read More

Skin Cancer Detection and Prevention

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With most of the United States experiencing warmer weather, increased sun exposure can lead to an increased risk of developing skin cancer. There are more new cases of skin cancer in the US each year than breast, prostate, lung, and colon cancers combined. The most dangerous form of skin cancer is melanoma, which if left untreated can metastasize to other locations within the body1. Detecting Skin Cancer...  Read More

Video: Genetic Background in Syngeneic Models

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Through this excerpt from Taconic Biosciences' Webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice," Dr. Philip Dubé considers the role of genetic background when identifying the proper syngeneic model as well as the importance of validating substrain and specific cell line. Syngeneic models depend on the implanted tumor cell not being rejected by the immune system; it is crucial that cell lines are genetically matched to...  Read More

Metastatic Prostate Cancer Modeling with Humanized Mice

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Prostate cancer will likely remain among the leading causes of cancer-related deaths in men until improved therapies for advanced metastatic disease become available. According to Dr. Steve Kregel, a postdoctoral researcher working with Dr. Arul Chinnaiyan at the University of Michigan, a key barrier to improving prostate cancer therapies is the woefully inadequate models of metastatic disease used in preclinical drug testing. At the 2019 American Association...  Read More

Studying T Cell Distribution in Syngeneic Tumor Models

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In a recent article in The Journal of Pharmacology and Experimental Therapeutics, Khot et al. examined the pharmacokinetics (PK) of exogenously administered T cells in a syngeneic tumor model. As immuno-oncology therapeutics expand into cell-based therapies, such as CAR-T cells, this type of research is needed to support their development. Khot et al. provide valuable insight into the PK of T cell-based therapeutics in this new paper....  Read More

Market Growth of Immuno-oncology Drugs Improve Cancer Treatments

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Figure 1: Companies actively pursuing immunotherapies. Source: Trends in the Global Immuno-oncology Landscape (2018) The approval of Ipilimumab (Yervoy®, BMS) in 2011 finally offered hope to metastatic melanoma patients — and set off a revolution in cancer treatment. Since 2011, regulatory agencies have approved eleven more immunotherapy drugs. Immunotherapy research continues to explode. There are close to thirty approved drugs that stimulate the immune system to kill...  Read More

EACR 2019 Conference Series Review

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The EACR Conference on Immuno-Oncology attracted academic and pharmaceutical researchers from all over the world to the Casa Milà in Barcelona, Spain. Attendees shared their recent findings in fundamental and translational research and discussed clinical studies in immuno-oncology and immunotherapy. EACR 2019 Immuno-Oncology Conference Series This Insight only highlights a small fraction of the discussions, seminars and presentations from this year's conference series. Speakers Richard Flavell and...  Read More

What You Need to Know About Colorectal Cancer

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March is National Colorectal Cancer Awareness Month. To increase awareness, the Colorectal Cancer Alliance (CC Alliance) has launched a public awareness campaign called "Don't Assume". This organization aims to challenge assumptions about colorectal cancer through online, print, and social media marketing. Unfortunately, this type of cancer is the third most common cancer in the US and the second leading cause of cancer-related deaths1. While previous studies have...  Read More